How to delete profile folder

I using persona management and I have a bad user profile

I want to delete his Profile folder but I get "The action can't be completed because the folder or a file in it is open in another program"

I understand that the problem is to access to the folder {08C31585-259A-4341-9982-78E42EAF6106} inside .

Please help me it a little urgent

Thank in advance,

Rami